Frankenstein is a New York doctor and the supposed grandson of Victor Frankenstein, the protagonist of the 1818 novel Frankenstein written by Mary Shelley. Initially repulsed by his grandfather's work in recreating life from decaying flesh, which lead to him to pronounce his last name, "Fronk'-en-steen", due to people bringing up his relation of his grandfather. He is later ultimately inspired to carry on the experiments and creates a creature of his own.
In the 2007 musical, the character remains mostly the same. The university Frederick works at is identified as New York's best university, known as the "Johns, Miriam and Anthony Hopkins School of Medicine." He is ashamed to be a Frankenstein, insisting his name be pronounced "Fronkensteen" and that he is not a madman but a scientist. After learning that he has inherited his grandfather's castle in Transylvania, he is forced to resolve the issue of the property. Once inside the castle's main living room, Frederick falls asleep reading and dreams that his grandfather and ancestors encourage him to build a monster. He then decides to continue his grandfather's experiments.